Highly Efficient Pd/C-Catalyzed Suzuki Coupling Reaction of p-(un)Substituted Phenyl Halide with (p-Substituted phenyl) Boronic Acid

✍ Scribed by Ming-Gang Hu; Zhong-Wei An; Wei-Song Du; Jian Li; Ai-Ai Gao

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 51 KB
• Volume: 25
• Category: Article
• ISSN: 0256-7660
• DOI: 10.1002/cjoc.200790220

✦ Synopsis

Abstract

A highly efficient Pd/C‐catalyzed ligandless, heterogeneous Suzuki reaction of p‐(un)substituted phenyl halide with (p‐substituted phenyl)boronic acid in DMF/H~2~O solvent in a short reaction time (0.5 h) at 75 °C was developed. The key for such a catalytic system was the addition of 1 equivalent of tetrabutylammonium bromide. A wide variety of substituents can be tolerated and high yields of cross coupling products were achieved. The palladium catalyst can be easily recovered and reused without significantly decreasing its efficiency.