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Highly efficient conversion of fused 2-amino-4-aryl-4H-chromene-3-carbonitriles into fused 2-oxo-4-aryl-2H-chromene-3-carbonitriles using Vilsmeier conditions

โœ Scribed by Banothu, Janardhan; Velpula, Ravibabu; Gali, Rajitha; Bavantula, Rajitha; Crooks, Peter A.


Book ID
120349022
Publisher
Elsevier Science
Year
2013
Tongue
French
Weight
265 KB
Volume
54
Category
Article
ISSN
0040-4039

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2-Amino-8-oxo-tetrahydro-4H-chromene-3-carbonitriles were synthesized for the first time from a tandem Michael addition - cyclization reaction between cyclohexane-1,2-dione and benzylidenemalononitriles. An enantioselective synthesis of these compounds was achieved in moderate ee values (up to 63% e