Highly efficient asymmetric amination of β-keto esters catalyzed by chiral quaternary ammonium bromides

✍ Scribed by Quan Lan; Xisheng Wang; Rongjun He; Changhua Ding; Keiji Maruoka

• Book ID: 104096282
• Publisher: Elsevier Science
• Year: 2009
• Tongue: French
• Weight: 387 KB
• Volume: 50
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2009.02.041

✦ Synopsis

A highly efficient asymmetric amination of b-keto esters was achieved under phase transfer conditions using chiral quaternary ammonium bromide as a catalyst. The amination products were obtained in quantitative yields with up to 97% ee. One of the amination products represents a key intermediate for the preparation of aldose reductase inhibitor AS-3201.