Highly efficient and catalyst-free synthesis of unsymmetrical thioureas under solvent-free conditions

✍ Scribed by Azim Ziyaei Halimehjani; Yaghoub Pourshojaei; Mohammad R. Saidi

• Book ID: 104095944
• Publisher: Elsevier Science
• Year: 2009
• Tongue: French
• Weight: 161 KB
• Volume: 50
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2008.10.063

✦ Synopsis

A highly efficient and simple synthesis of unsymmetrical thioureas is reported based on the reaction of readily synthesized dithiocarbamates with amines, without using any catalyst under solvent-free conditions. The short reaction time, high yields, and solvent-free conditions are advantages of this method. We did not observe the formation of any symmetric disubstituted thiourea, under these reaction conditions.