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Highly effective enteral treatment of unconjugated hyperbilirubinemia in Gunn rats

โœ Scribed by Anja M. Hafkamp; Rick Havinga; Maarten Sinaasappel; Ronald P.J. Oude Elferink; Henkjan J. Verkade


Book ID
119426996
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
179 KB
Volume
124
Category
Article
ISSN
0016-5085

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We sought to develop an oral treatment for unconjugated hyperbilirubinemia. In the Gunn rat model of unconjugated hyperbilirubinemia, dietary supplementation with the lipase inhibitor orlistat (Orl) or with calcium phosphate (CaP) decreases plasma unconjugated bilirubin (UCB) levels. We determined w

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Tetrachlorodibenzo-p-dioxin, a potent inducer of microsomal cytochrome P448-dependent monoxygenases, and phototherapy both accelerate bilirubin metabolism and decrease jaundice in Gunn rats. The effects of combined treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin and light were studied in these ra