Highly divergent subtypes and new recombinant forms prevail in the HIV/AIDS epidemic in Angola: New insights into the origins of the AIDS pandemic
✍ Scribed by Inês Bártolo; Cheila Rocha; José Bartolomeu; António Gama; Rute Marcelino; Marlene Fonseca; Ana Mendes; Marta Epalanga; Patrícia Cavaco Silva; Nuno Taveira
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 829 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1567-1348
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✦ Synopsis
Angola, located in South-Western Africa, has a remarkably low HIV/AIDS prevalence in the adult population (3.7%). It is bordered in the North by the Democratic Republic of Congo (DRC) and Republic of Congo that are at the origin of human HIV-1 infections. It is, therefore, likely that HIV-1 strains circulating in Angola are genetically diverse and representative of the origin of the HIV/AIDS epidemic. The aim of this work was to investigate in detail the genetic diversity and molecular epidemiology of HIV-1 in Angola. Almost 400 sequences were obtained from the gag (p17), pol (PR and RT) and/or env (C2C3) genes of 159 HIV-1 infected patients living in eight provinces of Angola (