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Highly Diastereoselective Synthesis of New, Carbostyril-Based Type of Conformationally-Constrained β-Phenylserines.

✍ Scribed by Hisanori Ueki; Trevor K. Ellis; Masood A. Khan; Vadim A. Soloshonok


Publisher
John Wiley and Sons
Year
2003
Weight
129 KB
Volume
34
Category
Article
ISSN
0931-7597

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✍ Andrea Trabocchi; Claudia Lalli; Francesco Guarna; Antonio Guarna 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 156 KB

## Abstract A rigid bicyclic ketene was used to generate highly constrained polycyclic spiro‐β‐lactams through the Staudinger reaction. Depending on the imine component, high diastereoselectivity was observed in the process, leading to mainly the __cis__ diastereoisomer in the case of aromatic imin