Diastereoselective synthesis of 2,3,4-tr
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Jörg Lüßmann; Dieter Hoppe; Peter G. Jones; Christa Fittschen; George M. Sheldri
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Article
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1986
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Elsevier Science
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French
⚖ 227 KB
The acid-catalyzed ring opening of the title epoxide 1 takes place at the C-l atom with retention of configuration at C-2 to form 2,3-cis-2-hydroxy-substituted y-lactol deriva= tives 3 In basic media, nucleophiles attack the C-Atom with inversion of configuration yielding 2,3-trans-lactols 5. Oxidat