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Highly Diastereoselective Conjugate Additions of Monoorganocopper Reagents to Chiral Imides.

✍ Scribed by Jesse Dambacher; Robert Anness; Patrick Pollock; Mikael Bergdahl


Publisher
John Wiley and Sons
Year
2004
Weight
276 KB
Volume
35
Category
Article
ISSN
0931-7597

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Highly diastereoselective addition of si
✍ Hiroshi Shinokubo; Junichi Kondo; Atsushi Inoue; Koichiro Oshima πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 122 KB

Treatment of benzoate, formate, or trifluoroacetate esters with silyldibromomethyllithiums provides alkyl silyl mixed acetals via the 1,3-rearrangement of a silyl group from carbon to oxygen. A high level of asymmetric induction onto the acetal carbon is observed when chiral alkyl esters are employe