Highly Diastereoselective Addition of N-Boc-pyrrolidin-2-yllithium to Optically Active Ketimines − Synthesis of Enantiomerically Pure 1,3-Imidazolidin-2-ones and Diamines

Diastereoselective 1,2-Addition of Organ

Diastereoselective 1,2-Addition of Organometallic Reagents to Chiral Formylferrocenes Leading to Enantiomerically Pure Ferrocenyl Amino Alcohols: Application to Asymmetric Dialkylzinc Addition to Aldehydes and Synthesis of Optically Active 1,2-Homodisubstituted Ferrocenes

✍ Shin-ichi Fukuzawa; Daisuke Tsuchiya; Kae Sasamoto; Kohki Hirano; Makoto Ohtaguc 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 341 KB 👁 1 views

The chiral formylferrocenes 2-5 have been readily prepared in good yields by ortho-lithiation of the TMS-blocked orunblocked aminoferrocenes and subsequent reaction with DMF. The stereochemistry of the reaction of 2 with organometallic reagents has been examined. Reactions of 2 with Grignard and org