Highly Diastereo- and Enantioselective Mannich Reactions of Synthetically Flexible Ketimines with Secondary Amine Organocatalysts

Highly Diastereo- and Enantioselective V

Highly Diastereo- and Enantioselective Vinylogous Mannich Reactions of Fluorinated Aldimines with Siloxyfurans

✍ Qian-Yi Zhao; Zhi-Liang Yuan; Min Shi 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 230 KB

## Abstract A highly regio‐ and enantioselective asymmetric vinylogous Mannich reaction of readily available fluorinated aldimines bearing a chiral auxiliary [(__S__)‐1‐phenylethyl group] with siloxyfurans to afford chiral fluorine‐containing γ‐butenolide or γ‐lactone derivatives has been developed