Higher laryngeal preservation rate after CO2 laser surgery compared with radiotherapy in T1a glottic laryngeal carcinoma
✍ Scribed by Michiel L. Schrijvers; Eva L. van Riel; Johannes A. Langendijk; Frederik G. Dikkers; Ed Schuuring; Jacqueline E. van der Wal; Bernard F. A. M. van der Laan
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 131 KB
- Volume
- 31
- Category
- Article
- ISSN
- 1043-3074
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✦ Synopsis
Abstract
Background.
Clinical outcome of endoscopic CO~2~ laser surgery and radiotherapy in early‐stage glottic laryngeal carcinoma is difficult to compare because of differences in treatment selection and patient groups. Therefore, we compared local control, overall survival, and laryngeal preservation in a homogenous group of patients with T1a glottic carcinoma with normal/diminished mucosal wave treated with either CO~2~ laser surgery or radiotherapy.
Methods.
Retrospective survival analysis was performed on 100 patients with T1a glottic carcinoma treated with CO~2~ laser surgery (n = 49) or radiotherapy (n = 51), diagnosed at the University Medical Center Groningen between 1990 and 2004.
Results.
No significant differences in local control and overall survival were found. Ultimate 5‐year laryngeal preservation was significantly better in the CO~2~ laser surgery group (95% vs 77%, p = .043).
Conclusion.
Patients with T1a glottic carcinoma with normal/diminished mucosal wave treated with CO~2~ laser surgery had a significantly better laryngeal preservation rate than patients treated with radiotherapy. © 2009 Wiley Periodicals, Inc. Head Neck, 2009