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High-yield expression of Therapeutic proteins with extended serum half-life in tobacco cells

✍ Scribed by Jianfeng Xu; Marcia J. Kieliszewski


Book ID
118473205
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
60 KB
Volume
136
Category
Article
ISSN
0168-1656

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High-yields and extended serum half-life
✍ Jianfeng Xu; Li Tan; Kenneth J. Goodrum; Marcia J. Kieliszewski πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 343 KB

## Abstract Therapeutic proteins like human interferon Ξ±2 generally possess short serum half‐lives due to their small size, hence rapid renal clearance, and susceptibility to serum proteases. Chemical derivatization, such as addition of polyethylene glycol (PEG) groups overcomes both problems, but