High-yields and extended serum half-life
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Jianfeng Xu; Li Tan; Kenneth J. Goodrum; Marcia J. Kieliszewski
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Article
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2007
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John Wiley and Sons
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English
β 343 KB
## Abstract Therapeutic proteins like human interferon Ξ±2 generally possess short serum halfβlives due to their small size, hence rapid renal clearance, and susceptibility to serum proteases. Chemical derivatization, such as addition of polyethylene glycol (PEG) groups overcomes both problems, but