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High urinary excretion of lipid peroxidation-derived DNA damage in patients with cancer-prone liver diseases

✍ Scribed by Jagadeesan Nair; Petcharin Srivatanakul; Claudia Haas; Adisorn Jedpiyawongse; Thiravud Khuhaprema; Helmut K. Seitz; Helmut Bartsch


Book ID
113809384
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
607 KB
Volume
683
Category
Article
ISSN
0027-5107

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Accumulation of lipid peroxidation-deriv
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## Abstract In thalassemia patients, iron overload can stimulate lipid peroxidation (LPO), thereby generating miscoding DNA adducts. Adducted DNA was measured in the lymphocytes of β‐Thal/Hb E patients and healthy controls and in the organs of thalassemic mice. Ξ΅dA, Ξ΅dC and M~1~dG residues were qua