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High tumor necrosis factor-α in levels in cerebrospinal fluid of cobalamin-deficient patients

✍ Scribed by Giuseppe Scalabrino; Marinella Carpo; Fabrizia Bamonti; Simona Pizzinelli; Carla D'Avino; Nereo Bresolin; Giuseppe Meucci; Vittorio Martinelli; Gian Carlo Comi; Maddalena Peracchi

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 117 KB
Volume: 56
Category: Article
ISSN: 0364-5134
DOI: 10.1002/ana.20325

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

We studied 14 patients with neurological manifestations of subacute combined degeneration (SCD) and 40 control patients not cobalamin (Cbl)‐deficient. The cerebrospinal fluid (CSF) markers of Cbl deficiency (Cbl and total homocysteine [tHCYS] levels) and the CSF levels of tumor necrosis factor (TNF)‐α and epidermal growth factor (EGF) were measured. Significantly higher levels of tHCYS and TNF‐α, and significantly lower levels of Cbl and EGF were found in the SCD patients. In human CSF, as in human serum and the rat central nervous system, decreased Cbl concentrations are concomitant with an increase in TNF‐α and a decrease in EGF‐levels. Ann Neurol 2004;56:886–890

An Erratum has been published for this article in Ann Neurol 57: 304, 2005.

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