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High-throughput synthesis and screening of platinum drug candidates

โœ Scribed by Christopher J. Ziegler; Adam P. Silverman; Stephen J. Lippard


Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
254 KB
Volume
5
Category
Article
ISSN
1432-1327

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Synthesis and DNA Interaction of Platinu
โœ Mariana S. Damian; Hanna K. Hedman; Sofi K. C. Elmroth; Ulf Diederichsen ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 457 KB

## Abstract Modification and optimization of the anticancer drug cisplatin is of interest with respect to selective cell targeting and DNA binding efficiency. Attractive approaches contain both, modification of the platinum coordination sphere and design of hybrid molecules of the cisplatin binding