High-Throughput Self-Interaction Chromatography: Applications in Protein Formulation Prediction

Application of a novel in silico high-th

Application of a novel in silico high-throughput screen to identify selective inhibitors for protein–protein interactions

✍ Catherine Joce; Joshua A. Stahl; Mitesh Shridhar; Mark R. Hutchinson; Linda R. W 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 447 KB

Increasing numbers of target protein structures available for computational studies makes the structure-based screening paradigm more attractive for initial hit indentification. We have developed a novel in silico screening methodology incorporating Molecular Mechanics (MM)/implicit solvent methods