High-Throughput Screening in Drug Discovery (Methods and Principles in Medicinal Chemistry)

✍ Scribed by Jörg Hüser (Editor), Raimund Mannhold, Hugo Kubinyi, Gerd Folkers (Series Editors)

Publisher: Wiley-VCH
Year: 2006
Tongue: English
Leaves: 362
Series: Methods and Principles in Medicinal Chemistry 35
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

Content: The basic principles of GRID / Peter Goodford -- Calculation and application of molecular interaction fields / Rebecca C. Wade -- Protein selectivity studies using GRID-MIFs / Thomas Fox -- FLAP: 4-point pharmacophore fingerprints from GRID / Francesca Perrucio ... [et al.] -- The complexity of molecular interaction: molecular shape fingerprints by the PathFinder approach / Iain McLay ... [et al.] -- Alignment-independent descriptors from molecular interaction fields / Manuel Pastor -- 3D-QSAR using the GRID/GOLPE approach / Wolfgang Sippl -- Use of MIF-based VolSurf descriptors in physicochemical and pharmacokinetic studies / Raimund Mannhold ... [et al.] -- Molecular interaction fields in ADME and safety / Giovanni Cianchetta ... [et al.] -- Progress in ADME prediction using GRID-molecular interaction fields / Ismael Zamora ... [et al.] -- Rapid ADME filters for lead discovery / Tudor I. Oprea ... [et al.] -- GRID-derived molecular interaction fields for predicting the site of metabolism in human cytochromes / Gabriele Cruciani ... [et al.]

📜 SIMILAR VOLUMES

High-Throughput Screening in Drug Discov

📁 High-Throughput Screening in Drug Discovery, Volume 35

✍ Raimund Mannhold, Hugo Kubinyi, Gerd Folkers(eds.) 📂 Library 📅 2006 🌐 English

Backed by leading authorities, this is a professional guide to successful compound screening in pharmaceutical research and chemical biology, including the chemoinformatic tools needed for correct data evaluation. Chapter authors from leading pharmaceutical companies as well as from Harvard Universi

Protein Crystallography in Drug Discover

📁 Protein Crystallography in Drug Discovery (Methods and Principles in Medicinal Chemistry)

✍ Robert E. Babine 📂 Library 📅 2004 🌐 English

The rational, structure-based approach has become standard in present-day drug design. As a consequence, the availability of high-resolution structures of target proteins is more often than not the basis for an entire drug development program. Protein structures suited for rational drug design are a

Chemogenomics in Drug Discovery: A Medic

📁 Chemogenomics in Drug Discovery: A Medicinal Chemistry Perspective (Methods and Principles in Medicinal Chemistry)

✍ Hugo Kubinyi, Gerhard Muller, Raimund Mannhold, Gerd Folkers 📂 Library 📅 2004 🏛 Wiley-VCH Verlag GmbH & Co. 🌐 English

Chemogenomics brings together the most powerful concepts in modern chemistry and biology, linking combinatorial chemistry with genomics and proteomics.The first reference devoted to the topic, this up-to-date resource covers all stages of the early drug discovery process, from target selection to co

Mass Spectrometry in Medicinal Chemistry

📁 Mass Spectrometry in Medicinal Chemistry: Applications in Drug Discovery (Methods and Principles in Medicinal Chemistry)

✍ Klaus Wanner, Georg Höfner 📂 Library 📅 2007 🌐 English

Fragment-based Approaches in Drug Discov

📁 Fragment-based Approaches in Drug Discovery (Methods and Principles in Medicinal Chemistry)

✍ Wolfgang Jahnke, Daniel A. Erlanson (Editors), Raimund Mannhold, Hugo Kubinyi, G 📂 Library 📅 2006 🏛 Wiley-VCH 🌐 English

This first systematic summary of the impact of fragment-based approaches on the drug development process provides essential information that was previously unavailable. Adopting a practice-oriented approach, this represents a book by professionals for professionals, tailor-made for drug developers i

A Practical Guide to Assay Development a

📁 A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery (Critical Reviews in Combinatorial Chemistry)

✍ Taosheng Chen 📂 Library 📅 2009 🌐 English

The development of suitable assays, the integration of appropriate technology, and the effective management of the essential infrastructure are all critical to the success of any high-throughput screening (HTS) endeavor. However, few scientists have the multidisciplinary experience needed to control