High-throughput microplate assay for the determination of drug partition coefficients
✍ Scribed by Magalhães, Luís M; Nunes, Cláudia; Lúcio, Marlene; Segundo, Marcela A; Reis, Salette; Lima, José L F C
- Book ID
- 109946819
- Publisher
- Nature Publishing Group
- Year
- 2010
- Tongue
- English
- Weight
- 805 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1750-2799
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract We show that highly porous silica‐based nanoparticles prepared via micro‐emulsion and sol–gel techniques are stable colloids in aqueous solution. By incorporating a magnetic core into the porous silica nano‐composite, it is found that the material can be rapidly separated (precipitated)
P-glycoprotein (P-gp) is a multidrug transporter responsible for resistance to anticancer chemotherapy and physiologically involved in absorption, distribution, and excretion of a large number of hydrophobic xenobiotics. P-gp exhibits both an ATPase activity correlated with its drug transport functi