M13 phages that display random disulfide constrained heptapeptides on their gpIII proteins were used to select for high affinity ligands to hepatitis B core antigen (HBcAg). Phages bearing the amino acid sequences C-WSFFSNI-C and C-WPFWGPW-C were isolated, and a binding assay in solution showed that
✦ LIBER ✦
High-Throughput Method for Ranking the Affinity of Peptide Ligands Selected from Phage Display Libraries
✍ Scribed by González-Techera, A.; Umpiérrez-Failache, M.; Cardozo, S.; Obal, G.; Pritsch, O.; Last, J. A.; Gee, S. J.; Hammock, B. D.; González-Sapienza, G.
- Book ID
- 125968073
- Publisher
- American Chemical Society
- Year
- 2008
- Tongue
- English
- Weight
- 957 KB
- Volume
- 19
- Category
- Article
- ISSN
- 1043-1802
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## Abstract Compelling evidence suggests that vascular endothelial growth factor (VEGF) and its receptors play an important role in angiogenesis associated with tumor growth and metastasis. VEGF exerts its biologic activities through 2 transmembrane tyrosine kinase receptors: the __fms__‐like tyros