High-throughput mass spectrometry: the mechanism of sudan azo dye fragmentation by ESI tandem mass spectrometry and extensive deuterium labeling experiments
✍ Scribed by Leonardo Di Donna; Antonio De Nino; Loredana Maiuolo; Fabio Mazzotti; Anna Napoli; Raffaele Salerno; Giovanni Sindona
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 154 KB
- Volume
- 42
- Category
- Article
- ISSN
- 1076-5174
- DOI
- 10.1002/jms.1236
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✦ Synopsis
Abstract
The investigation of the gas‐phase chemistry of azo compounds by mass spectrometry dates back to the introduction of this peculiar research field into the armory of physical organic chemistry tools. The mechanism of the fragmentation of the azo double bond from the protonated precursor is discussed with reference to the behavior of deuterium‐labeled reference compounds. The investigated molecules belong to the sudan family and the results can be used for the detection of these potential carcinogenic compounds in different matrices by means of the isotope dilution method. Copyright © 2007 John Wiley & Sons, Ltd.