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High-throughput determination of theophylline and caffeine in human serum by conventional liquid chromatography-mass spectrometry

✍ Scribed by Tetsuya Arinobu; Hideki Hattori; Takeshi Kumazawa; Xiao-Pen Lee; Yoko Mizutani; Takao Katase; Sadao Kojima; Takayuki Omori; Rina Kaneko; Akira Ishii; Hiroshi Seno


Book ID
111708096
Publisher
Springer Japan
Year
2008
Tongue
English
Weight
327 KB
Volume
27
Category
Article
ISSN
1860-8965

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A liquid chromatographic/tandem mass spectrometric (LC/MS/MS) assay was developed for the quantitative determination of olanzapine (LY170053, OLZ) in human plasma and serum. Bond Elut solid-phase extraction C 2 cartridges (single cartridge or 96-well format), in conjunction with a positive pressure