Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase (NOS), may be related to reduced biosynthesis of nitric oxide in diseases associated with accelerated atherosclerosis. The closely related compound symmetric dimethylarginine (SDMA) does not inhibit NOS, but may com
High-throughput CZE-UV determination of arginine and dimethylated arginines in human plasma
β Scribed by Angelo Zinellu; Salvatore Sotgia; Elisabetta Zinellu; Antonio Pinna; Francesco Carta; Leonardo Gaspa; Luca Deiana; Ciriaco Carru
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 342 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0173-0835
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## Abstract Arginine (ARG) is a substrate for endogenous nitric oxide (NO) production whereas its metabolite, asymmetric dimethylarginine (ADMA), acts as an inhibitor. Sufficient NO production is essential for cardiovascular key functions, thus elevated concentration levels of ADMA are related to a
## Abstract Therapeutic drug monitoring is pivotal to improve the management of HIV infection. Here, a new HPLCβUV method to quantify simultaneously maraviroc and raltegravir levels in human plasma is reported. Remarkably, this is the first method for maraviroc determination in human plasma. The vo