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High-throughput bisulfite sequencing in mammalian genomes

โœ Scribed by Zachary D. Smith; Hongcang Gu; Christoph Bock; Andreas Gnirke; Alexander Meissner


Book ID
116987073
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
367 KB
Volume
48
Category
Article
ISSN
1046-2023

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## Abstract Siteโ€specific recognition of duplex DNA by triplexโ€forming oligonucleotides (TFOs) provides a promising approach to manipulate mammalian genomes. A prerequisite for successful gene targeting using this approach is that the targeted gene must contain specific, highโ€affinity TFO target se