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High temperature (GC)2 and (GC)2/CI-MS of nucleosides: Analysis of purinyl nucleoside isomer composition

✍ Scribed by Fischer, P. ;Lösch, G. R. ;Müller, D.

Publisher: John Wiley and Sons
Year: 1980
Tongue: English
Weight: 315 KB
Volume: 3
Category: Article
ISSN: 0935-6304
DOI: 10.1002/jhrc.1240030402

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✦ Synopsis

Abstract

The analysis of low‐volatile polar nucleosides by (GC)^2^/FID and (GC)^2^/CI‐MS, employing HMDS‐deactivated glass capillary columns and on‐column injection, is described. The four linkage isomers of a specific nucleoside, formed in the synthetic procedure, are in each case sufficiently well separated in the chromatogram; GC/CI‐MS allows for a differentiation of N‐7 and N‐9 linkage isomers.

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