High steady-state levels of uric acid produced in rats by dietary training and potassium oxonate
✍ Scribed by Jerold Newburger; Ting-Feng Hsu; Alan B. Combs
- Book ID
- 102403315
- Publisher
- John Wiley and Sons
- Year
- 1979
- Tongue
- English
- Weight
- 242 KB
- Volume
- 68
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
✦ Synopsis
0 T o reduce the inherent variability in serum uric acid levels of animals allowed ad libitum exposure to food containing potassium oxonate and uric acid, male Sprague-Dawley rats were trained to eat their daily food allotment in a 1.25-hr period each morning. After training, the rats were fed a food mixture containing 5% potassium oxonate and 2% uric acid (w/w each). Serum blood levels of uric acid reached a steady state within 2 hr; these levels were maintained for an additional 4 hr. It is believed that the stomach emptying rate is a zero-order process under these experimental conditions.
Keyphrases Uric acid-steady-state serum levels. rats, dietary training, potassium oxonate Hyperuricemia-animal models, rats 0 Potassium oxonate-used to produce hyperuricemia in rats Calbiochem, San Diego. Calif. Fisher Scientific Co., Fair Lawn, N.J.