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High speed analysis of underivatized drugs by gas chromatography-mass spectrometry

✍ Scribed by Kokanovich, J. D. ;Simonick, T. F. ;Watts, V. W.

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 345 KB
Volume: 12
Category: Article
ISSN: 0935-6304
DOI: 10.1002/jhrc.1240120115

No coin nor oath required. For personal study only.

✦ Synopsis

septum, and inlet purge rates. The advantages of rapid automatic inlections along with specific recommendations for splitless injections into narrow-bore columns also appear in the literature [3,4,7,16,17] Theimportance ofm~ectionportlinerpreparation for certain compounds such as underlvatlzed drugs has been noted by a number of authors [4,9,181 The technique Of choice for many types Of forensic drug 'Onfirmations is gas chromatography/mass spectrometry (GC'MS)' Significant amounts of analytical time can be involved in a GC/MS run. The use df a 0.1 mm i.d. fused silica capillary column with hydrogen carrier gas can significantly increase the speed of an analysis without sacrificing resolution. Nanogram levels of underivatired drugs, from amphetamine to strychnine, can be eluted in less than twelve minutes. The multitasking system 2 ExDerimental ~~ permits data acquisition, while performing data reduction on the previous run.

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