## Abstract Maps of cytoarchitectonically defined cortical areas have proven to be a valuable tool for anatomic localization of activated brain regions revealed by functional imaging studies. However, architectonic data require observations in a sample of postmortem brains. They can only be used re
High spatial resolution MRI and proton MRS of human frontal cortex
✍ Scribed by Dolores López-Villegas; Hirohiko Kimura; Supoch Tunlayadechanont; Robert E. Lenkinski
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 775 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0952-3480
No coin nor oath required. For personal study only.
✦ Synopsis
High-resolution MR imaging (312 Frn in plane resolution) and MR spectroscopy (0.36 cm3 nominal voxel) have been performed on human frontal cortex using a 3 in surface coil. Localized proton spectra have been obtained from contiguous 6 x 6 x 10 mm voxels using one-dimensional phase encoding, TR 2000 ms and TE 31 ms. Seven healthy subjects were studied using this approach. The spectra from frontal gray matter showed a reproducible pattern characterized by a choline to creatine and N-acetylaspartate to creatine ratio significantly lower than those from cortical white matter. These metabolite ratio differences reflect the lower choline and higher creatine content in gray matter. These preliminary results show the potential of this high spatial-resolution approach for studying brain cortex.
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