High Serum Beta-2-Microglobulin Levels and Circulating Immune Complexes Containing βm AND Anti-βm Antibodies in Felty's Syndrome
✍ Scribed by AndráS Falus; Allan Wiik; Henrik Permin; Ivan Brandslund; Sven-Erik Svehag
- Book ID
- 102752746
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- English
- Weight
- 627 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0004-3591
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✦ Synopsis
Serum beta-2-microglobulin (am) levels, incidence and levels of anti-am autoantibodies, and quantity of circulating macromolecular complexes containing a m were studied in patients with Felty's syndrome (FS), joint-restricted rheumatoid arthritis (RA), and healthy controls. The serum a m concentrations detected in the FS group (6.95 2 2.9 mghiter) greatly exceeded those of the RA group (3.4 f 1.2 mghiter) and the control group (1.42 -C 0.69 mghter). Autoantibodies to a m were frequent in the FS group. Circulating complexes containing a m , prepared by precipitation in 3% polyethylene glycol, were detected in 65% of FS and 35% of RA patients. In the majority of these cases the solid-phase Clq purified immune complexes also contained &m. Detection of anti-&m antibodies in a significant part of complexes containing Pzm suggests