High-sensitivity single-shot perfusion-weighted fMRI

✍ Scribed by Jeff H. Duyn; Charlene X. Tan; Peter van Gelderen; Martin N. Yongbi

• Book ID: 102530096
• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: English
• Weight: 356 KB
• Volume: 46
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.1163

✦ Synopsis

A method is presented for measurement of perfusion changes during brain activation using a single-shot pulsed spin labeling technique. By employing a double-inversion labeling strategy, stationary tissue (background) signal was suppressed while minimally affecting perfusion sensitivity. This allowed omission of the otherwise required reference scan, resulting in twofold-improved temporal resolution. The method was applied to visual and motor cortex activation studies in humans, and compared to standard FAIR-type perfusion labeling techniques. Experiments performed at 1.5T and 3.0T indicate a close to 90% suppression of background signal, at a cost of an 11% and 9%, respectively, reduction in perfusion signal. Combined with the twofold increase in signal averaging, and a reduction in background signal fluctuations, this resulted in a 64% (1.5T, N = 3) and a 128% (3T, N = 4) overall improvement in sensitivity for the detection of activation-related perfusion changes. Magn Reson Med 46:88-94, 2001. Published 2001 Wiley-Liss, Inc.