𝔖 Bobbio Scriptorium
✦   LIBER   ✦

High-sensitivity Orbitrap mass analysis of intact macromolecular assemblies

✍ Scribed by Rose, Rebecca J; Damoc, Eugen; Denisov, Eduard; Makarov, Alexander; Heck, Albert J R

Book ID
117994262
Publisher
Nature Publishing Group
Year
2012
Tongue
English
Weight
619 KB
Volume
9
Category
Article
ISSN
1552-4450

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## Abstract Recombinant monoclonal antibodies (MAbs) can be heterogeneous due to modifications that can occur during expression, purification or during storage. These large multichain proteins (∼150 kDa) are structurally challenging for detailed characterization to identify the sites of modificatio