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High Risk of Colorectal and Endometrial Cancer in Ashkenazi Families With the MSH2 A636P Founder Mutation

✍ Scribed by Bhramar Mukherjee; Gad Rennert; Jaeil Ahn; Sara Dishon; Flavio Lejbkowicz; Hedy S. Rennert; Stacey Shiovitz; Victor Moreno; Stephen B. Gruber

Book ID: 119979711
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 765 KB
Volume: 140
Category: Article
ISSN: 0016-5085
DOI: 10.1053/j.gastro.2011.02.071

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## Abstract ## BACKGROUND Hereditary nonpolyposis colorectal carcinoma (HNPCC) significantly raises the risk of developing colorectal carcinoma (CRC) and other extracolonic tumors. It is defined by the Amsterdam Criteria and is associated with germline mutations in mismatch repair genes, primarily