𝔖 Bobbio Scriptorium
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High-risk human papillomavirus types in cytologically normal cervical scrapes from Kenya

✍ Scribed by J. Czeglédy; K. O. Rogo; M. Evander; G. Wadell

Book ID
104657641
Publisher
Springer-Verlag
Year
1992
Tongue
English
Weight
425 KB
Volume
180
Category
Article
ISSN
0300-8584

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✦ Synopsis

Seventy-seven women with normal cervical cytology on routine visit to a family planning clinic in Nairobi, Kenya, were analysed for genital human papillomavirus (HPV) types by polymerase chain reaction (PCR). We applied a general primer pair (GP60/GP124) recognising sequences conserved among HPV types 6, 11, 16, 18, 31 and 33. Of the 77 specimens tested 15 (19.5%) proved to be positive for genital HPV. Amplification products were examined for the presence of high-risk HPV types by Slot-blot hybridization. Out of the 15 PCR-positive samples, 4 were positive for HPV 16.3 for HPV 18, while 1 contained both HPV 16 and 33. HPV DNA prevalence in this group of women from a "high-risk" area is similar to that in "low-risk" Swedish women but much lower than in cervical cancer samples from the same region.

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