High-risk human papillomavirus infection of the genital tract of women with a previous history or current high-grade vulvar intraepithelial neoplasia

✍ Scribed by Frederic Goffin; Marie-Hélène Mayrand; Philippe Gauthier; A. Alobaid; Christian Lussier; Diane Provencher; Pierre Drouin; Eduardo L. Franco; François Coutlée

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 101 KB
• Volume: 78
• Category: Article
• ISSN: 0146-6615
• DOI: 10.1002/jmv.20628

✦ Synopsis

Abstract

Human papillomavirus (HPV) infection is associated with high‐grade vulvar intraepithelial neoplasia (VIN‐3). The prevalence of anogenital HPV infection in women with previously treated VIN‐3 has not been documented yet. This cross‐sectional study compared high‐risk HPV DNA detection rates in women with past (n = 30) and current (n = 22) VIN‐3 to those without current or past VIN (n = 86). HPV DNA was detected in vulvar and cervical samples with Hybrid Capture 2 (HC‐2). Smoking was associated in multivariate analysis with current VIN‐3 (odds ratio (OR) 8.3, 95% confidence interval (CI) 2.0–8.2) and any VIN‐3 history (OR 6.5, 95% CI 2.5–16.5). High‐risk HPV DNA was found on the vulva of 64%, 33%, and 20% of women with current VIN‐3, past VIN‐3, and without previous or current VIN, respectively. After controlling for age and smoking, high‐risk HPV vulvar infection was associated with cervical high‐risk HPV infection (OR 8.6, 95% CI 2.8–26.5; P = 0.001). After controlling for age, HPV infection was more often multifocal in women with current VIN‐3 compared to women with previous but no current VIN‐3 lesion (OR 17.6, 95% CI 1.4–227.2). Multifocal vulvar HPV infection was detected in women with previous or active VIN‐3. Longitudinal studies are required to determine if the multifocality of HPV infection on the vulva could explain the high recurrence rate of VIN‐3. J. Med. Virol. 78:814–819, 2006. © 2006 Wiley‐Liss, Inc.