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High-risk human papillomavirus and cervical lymph node metastasis in patients with oropharyngeal cancer

✍ Scribed by Young-Hoon Joo; Chan-Kwon Jung; Dong-Il Sun; Jun-Ook Park; Kwang-Jae Cho; Min-Sik Kim

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
160 KB
Volume
34
Category
Article
ISSN
1043-3074

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✦ Synopsis

Abstract

Background

The purpose of this study was to determine the role of high‐risk human papillomavirus (HPV) in lymph node metastasis and the depth of invasion in oropharyngeal cancer.

Methods

The study included patients with 90 oral carcinomas and 66 oropharyngeal carcinomas. High‐risk HPV in situ hybridization was performed to detect HPV infection.

Results

The positive rate of high‐risk HPV in situ hybridization was 15.4% (24 of 156). There was a significant difference in the fraction of positive high‐risk HPV between oral (6.7%) and oropharyngeal (27.3%) cancers (p < .000). Significant correlations were found between positive high‐risk HPV and cervical lymph node metastasis, tumor depth of invasion in patients with oropharyngeal cancer (p = .002, p = .016, respectively). There was a statistically significant association between high‐risk HPV positivity and the disease‐specific survival in patients with oropharyngeal cancer (p = .035).

Conclusion

High‐risk HPV infection was significantly related to cervical lymph node metastasis and depth of invasion in patients with oropharyngeal cancer. © 2011 Wiley Periodicals, Inc. Head Neck, 2012

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