High-resolution structure of HLA-A∗0201 in complex with a tumour-specific antigenic peptide encoded by the MAGE-A4 gene

Crystal structures of HLA-A*0201 complex

Crystal structures of HLA-A*0201 complexed with antigenic peptides with either the amino- or carboxyl-terminal group substituted by a methyl group

✍ Marlène Bouvier; Hwai-Chen Guo; Kathrine J. Smith; Don C. Wiley 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 331 KB

The crystal structures of class I major histocompatibility complex (MHC) molecules complexed with antigenic peptides revealed a network of hydrogen bonds between the charged amino-and carboxyl-termini of the peptides and conserved MHC residues at both ends of the peptide binding site. These interact