High-resolution solid-state carbon-13 nuclear magnetic resonance spectra of mofebutazone, phenylbutazone, and oxyphenbutazone in relation to X-ray crystallographic data
✍ Scribed by M. Stoltz; D. W. Oliver; P. L. Wessels; A. A. Chalmers
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 795 KB
- Volume
- 80
- Category
- Article
- ISSN
- 0022-3549
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✦ Synopsis
The solid-state 13C NMR spectra of mofebutazone, phenylbutazone, and oxyphenbutazone monohydrate and anhydrate are presented. The crystal structures of these pyrazolidinedione derivatives, obtained by single-crystal X-ray analysis, were previously reported, revealing distinct differences in crystal structure. In this report, the chemical shift values observed for the solid-state 13C spectra are related to the chemical environment of the various carbon atoms and compared with the crystallographic data. Results indicate that solid-state NMR spectroscopy is potentially useful in the study of drugs in the solid state.