## Abstract High‐resolution magic angle spinning (HRMAS) ^1^H NMR spectroscopy is ideal for monitoring the metabolic environment within tissues, particularly when spectra are weighted by physical properties such as __T__~1~ and __T__~2~ relaxation times and apparent diffusion coefficients (ADCs). I
✦ LIBER ✦
High-Resolution Magic Angle Spinning 1H NMR Spectroscopy of Intact Liver and Kidney: Optimization of Sample Preparation Procedures and Biochemical Stability of Tissue during Spectral Acquisition
✍ Scribed by N.J. Waters; S. Garrod; R.D. Farrant; J.N. Haselden; S.C. Connor; J. Connelly; J.C. Lindon; E. Holmes; J.K. Nicholson
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 137 KB
- Volume
- 282
- Category
- Article
- ISSN
- 0003-2697
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## Abstract The metabolic consequences of xenobiotic‐induced toxicity were investigated using high‐resolution magic angle spinning (MAS) NMR spectroscopy of intact tissue. Renal papillary necrosis (RPN) was induced in Sprague‐Dawley rats (n = 12) via a single i.p. dose of 250 mg/kg 2‐bromoethanamin