High resolution magic angle spinning 1H NMR of childhood brain and nervous system tumours
β Scribed by Martin Wilson; Nigel P Davies; Marie-Anne Brundler; Carmel McConville; Richard G Grundy; Andrew C Peet
- Book ID
- 119902025
- Publisher
- BioMed Central
- Year
- 2009
- Tongue
- English
- Weight
- 346 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1476-4598
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## Abstract It is shown that highβresolution ^1^H NMR spectra of intact excised tissues and organs can be obtained by rotating the sample slowly about an axis at the magic angle of 54Β°44β² with the external magnetic field. In this way tissue and cellular damage invoked by standard magic angle spinni
## Abstract NMRβvisible lipid signals detected __in vivo__ by ^1^H MRS are associated with tumour aggression and believed to arise from cytoplasmic lipid droplets. Highβresolution magic angle spinning (HRMAS) ^1^H MRS and Nile Red staining were performed on human brain tumour biopsy specimens to in
## Abstract Highβresolution magic angle spinning (HRMAS) ^1^H NMR spectroscopy is ideal for monitoring the metabolic environment within tissues, particularly when spectra are weighted by physical properties such as __T__~1~ and __T__~2~ relaxation times and apparent diffusion coefficients (ADCs). I