𝔖 Bobbio Scriptorium
✦   LIBER   ✦

High-resolution in vivo CBV mapping with MRI in wild-type mice

✍ Scribed by Ed X. Wu; Kelvin K. Wong; Martin Andrassy; Haiying Tang

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
657 KB
Volume
49
Category
Article
ISSN
0740-3194

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

NMR microimaging has the potential to elucidate cerebrovascular abnormalities in mouse models. In this study, the relative regional cerebral blood volume (CBV) map is presented for C57BL6/J wild‐type mice. The CBV mapping was based on changes in the steady‐state NMR transverse relaxation rate (Δ__R__~2~) associated with the presence of a superparamagnetic intravascular contrast agent (MION) with a long blood halflife. The experiments were performed at 9.4 T at a voxel size of 100 μm × 100 μm × 600 μm. Fine details, such as the hippocampal and olfactory bulb area, were visualized in the CBV map. The relative regional CBV values of various brain regions were measured. The Δ__R__~2~ dosage dependency and MION tissue clearance in mouse are also reported. Magn Reson Med 49:765–770, 2003. © 2003 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

High-resolution contrast-enhanced MRI of
High-resolution contrast-enhanced MRI of atherosclerosis with digital cardiac and respiratory gating in mice
✍ Hasan Alsaid; Maher Sabbah; Zakaria Bendahmane; Odette Fokapu; Jacques Felblinge 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 426 KB

## Abstract Atherosclerosis initially develops predominantly at the aortic root and carotid origin, where effective visualization in mice requires efficient cardiac and respiratory gating. The present study sought to first compare the high‐resolution MRI gating performance of two digital gating str

In vivo qualitative assessments of artic
In vivo qualitative assessments of articular cartilage in the rabbit knee with high-resolution MRI at 3 T
✍ Didier Laurent; James Wasvary; Elizabeth O'Byrne; Markus Rudin 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 798 KB

## Abstract Proteoglycan (PG) loss and disruption of the collagen framework in cartilage are early events associated with osteoarthritis (OA). The feasibility of in vivo high‐resolution MRI assessments probing both macromolecules was explored in articular cartilage of the rabbit knee. One‐millimete

High-resolution MRI with cardiac and res
High-resolution MRI with cardiac and respiratory gating allows for accurate in vivo atherosclerotic plaque visualization in the murine aortic arch
✍ Frank Wiesmann; Michael Szimtenings; Alex Frydrychowicz; Ralf Illinger; Andreas 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 640 KB

## Abstract Genetically engineered mouse models provide enormous potential for investigation of the underlying mechanisms of atherosclerotic disease, but noninvasive imaging methods for analysis of atherosclerosis in mice are currently limited. This study aimed to demonstrate the feasibility of MRI

Mapping of retinal projections in the li
Mapping of retinal projections in the living rat using high-resolution 3D gradient-echo MRI with Mn2+-induced contrast
✍ Takashi Watanabe; Thomas Michaelis; Jens Frahm 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 294 KB

## Abstract This study describes the neuroaxonal tracing of the visual pathway in the living rat using high‐resolution __T__~1~‐weighted 3D gradient‐echo MRI (195 × 195 × 125 μm^3^) at 8, 24, 48, and 72 h after intraocular Mn^2+^ injection (0.1 μl of 1 M aqueous MnCl~2~). Best results were obtained