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High-resolution genomic profiling of male breast cancer reveals differences hidden behind the similarities with female breast cancer

✍ Scribed by Ida Johansson; Cecilia Nilsson; Pontus Berglund; Carina Strand; Göran Jönsson; Johan Staaf; Markus Ringnér; Heli Nevanlinna; Rosa B. Barkardottir; Åke Borg; Håkan Olsson; Lena Luts; Marie-Louise Fjällskog; Ingrid Hedenfalk


Publisher
Springer US
Year
2010
Tongue
English
Weight
797 KB
Volume
129
Category
Article
ISSN
0167-6806

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## Abstract The chromosomal region 11q13 is amplified in 15–20% of breast cancers; an event not only associated with estrogen receptor (ER) expression but also implicated in resistance to endocrine therapy. Coamplifications of the 11q13 and 8p12 regions are common, suggesting synergy between the am