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High-resolution deletion mapping of chromosome arm 1p in pancreatic cancer identifies a major consensus region at 1p35

✍ Scribed by Werner Hilgers; David J. Tang; Avrahom Y. Sugar; Manu C. Shekher; Ralph H. Hruban; Scott E. Kern

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 147 KB
Volume: 24
Category: Article
ISSN: 1045-2257
DOI: 10.1002/(sici)1098-2264(199904)24:4<351::aid-gcc9>3.0.co;2-y

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✦ Synopsis

Chromosomal arm 1p has long been suspected, on the basis of loss of heterozygosity (LOH) and other data, to harbor a tumor suppressor gene important in pancreatic carcinomas and other tumors. We constructed a high-resolution map of LOH at I p in a panel of pancreatic adenocarcinomas. Using 44 markers, we identified LOH on I p in 49% of 43 cancers. Breakpoints in 1p were identified in 15 of the carcinomas and could be used to ascertain consensus patterns. We found a major consensus region of LOH at 1p35 between loci D1S233 and D1S247. This region participates in the majority of LOH events on 1 p in pancreatic cancer. These data provide a roadmap for further regional mapping, homozygous deletion searches, comparison to LOH patterns seen in other tumor types, and prioritization of studies using candidate genes.

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