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High resolution crystal structures of the Escherichia coli lytic transglycosylase slt70 and its complex with a peptidoglycan fragment

โœ Scribed by Erik J van Asselt; Andy-Mark W.H Thunnissen; Bauke W Dijkstra


Book ID
115629544
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
1015 KB
Volume
291
Category
Article
ISSN
0022-2836

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Coumarin antibiotics, such as clorobiocin, novobiocin, and coumermycin A1, inhibit the supercoiling activity of gyrase by binding to the gyrase B (GyrB) subunit. Previous crystallographic studies of a 24-kDa Nterminal domain of GyrB from E. coli complexed with novobiocin and a cyclothialidine analog