The high-resolution crystal structure of
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Francis T.F. Tsai; Onkar M.P. Singh; Tadeusz Skarzynski; Alan J. Wonacott; Simon
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Article
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1997
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John Wiley and Sons
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English
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Coumarin antibiotics, such as clorobiocin, novobiocin, and coumermycin A1, inhibit the supercoiling activity of gyrase by binding to the gyrase B (GyrB) subunit. Previous crystallographic studies of a 24-kDa Nterminal domain of GyrB from E. coli complexed with novobiocin and a cyclothialidine analog