High resolution banding analysis of the reciprocal translocation t(6;9) in acute nonlymphocytic leukemia
β Scribed by Sverre Heim; Ulf Kristoffersson; Nils Mandahl; Felix Mitelman; Albert N. Bekassy; Stanislaw Garwicz; Thomas Wiebe
- Book ID
- 119103274
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- English
- Weight
- 397 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0165-4608
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## Abstract The genomic breakpoints in the t(15;17)(q22;q21), associated with acute promyelocytic leukemia (APL), are known to occur within three different __PML__ breakpoint cluster regions (bcr) on chromosome 15 and within __RARA__ intron 2 on chromosome 17; however, the precise mechanism by whic
The t(6;9) associated with a subtype of acute myeloid leukemia (AML) was shown t o generate a fusion between the 3' part of the CAN gene on chromosome 9 and the 5' part of the DEK gene on chromosome 6. The same part of the CAN gene appeared t o be involved in a case of acute undifferentiated leukemi