High-resolution analyses of gene copy number reveal new insights into the prognosis and progression of breast cancers

High-throughput amplicon scanning of the

High-throughput amplicon scanning of the TP53 gene in breast cancer using high-resolution fluorescent melting curve analyses and automatic mutation calling

✍ Roy Bastien; Tracey B. Lewis; Jason E. Hawkes; John F. Quackenbush; Thomas C. Ro 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 367 KB 👁 1 views

## Communicated by Ian N.M. Day Identifying mutations in the TP53 gene is important for cancer prognosis, predicting response to therapy, and determining genetic risk. We have developed a high-throughput scanning assay with automatic calling to detect TP53 mutations in DNA from fresh frozen (FF) a