𝔖 Bobbio Scriptorium
✦   LIBER   ✦

High-resolution 7T MRI of the human hippocampus in vivo

✍ Scribed by Bradley P. Thomas; E. Brian Welch; Blake D. Niederhauser; William O. Whetsell Jr; Adam W. Anderson; John C. Gore; Malcolm J. Avison; Jeffrey L. Creasy

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
703 KB
Volume
28
Category
Article
ISSN
1053-1807

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Purpose

To describe an initial experience imaging the human hippocampus in vivo using a 7T magnetic resonance (MR) scanner and a protocol developed for very high field neuroimaging.

Materials and Methods

Six normal subjects were scanned on a 7T whole body MR scanner equipped with a 16‐channel head coil. Sequences included a full field of view T1‐weighted 3D turbo field echo (T1W 3D TFE: time of acquisition (TA) = 08:58), T2*‐weighted 2D fast field echo (T2*W 2D FFE: TA = 05:20), and susceptibility‐weighted imaging (SWI: TA = 04:20). SWI data were postprocessed using a minimum intensity projection (minIP) algorithm. Total imaging time was 23 minutes.

Results

T1W 3D TFE images with 700 μm isotropic voxels provided excellent anatomic depiction of macroscopic hippocampal structures. T2*W 2D FFE images with 0.5 mm in‐plane resolution and 2.5 mm slice thickness provided clear discrimination of the Cornu Ammonis and the compilation of adjacent sublayers of the hippocampus. SWI images (0.5 mm in‐plane resolution, 1.0 mm slice thickness) delineated microvenous anatomy of the hippocampus.

Conclusion

In vivo 7T MR imaging can take advantage of higher signal‐to‐noise and novel contrast mechanisms to provide increased conspicuity of hippocampal anatomy. J. Magn. Reson. Imaging 2008;28:1266–1272. © 2008 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

The human hippocampus at 7 T—In vivo MRI
The human hippocampus at 7 T—In vivo MRI
✍ Jens M. Theysohn; O. Kraff; S. Maderwald; M.U. Schlamann; A. de Greiff; M. Forst 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 240 KB

## Abstract The human hippocampus plays a central role in various neuropsychiatric disorders, such as temporal lobe epilepsy (TLE), Alzheimer's dementia, mild cognitive impairment, and schizophrenia. Its volume, morphology, inner structure, and function are of scientific and clinical interest. Magn

In vivo qualitative assessments of artic
In vivo qualitative assessments of articular cartilage in the rabbit knee with high-resolution MRI at 3 T
✍ Didier Laurent; James Wasvary; Elizabeth O'Byrne; Markus Rudin 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 798 KB

## Abstract Proteoglycan (PG) loss and disruption of the collagen framework in cartilage are early events associated with osteoarthritis (OA). The feasibility of in vivo high‐resolution MRI assessments probing both macromolecules was explored in articular cartilage of the rabbit knee. One‐millimete

Automated segmentation of hippocampal su
Automated segmentation of hippocampal subfields from ultra-high resolution in vivo MRI
✍ Koen Van Leemput; Akram Bakkour; Thomas Benner; Graham Wiggins; Lawrence L. Wald 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 354 KB

## Abstract Recent developments in MRI data acquisition technology are starting to yield images that show anatomical features of the hippocampal formation at an unprecedented level of detail, providing the basis for hippocampal subfield measurement. However, a fundamental bottleneck in MRI studies