High rate of MDR-1 and heterogeneous pattern of MRP expression without gene amplification in endometrial cancer

✍ Scribed by Manel Esteller; Josep M. Martinez-Palones; Angel García; Jordi Xercavins; Jaume Reventós

• Publisher: John Wiley and Sons
• Year: 1995
• Tongue: French
• Weight: 908 KB
• Volume: 63
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910630609

✦ Synopsis

The present study was undertaken to determine the pattern of expression of 2 molecular markers of multidrug resistance, the MDR-I and MRP genes, in endometrial carcinomas from 50 untreated patients using a PCR semi-quantitative assay. In addition, PCR analysis of MDR-I and MRP gene amplification was obtained in each case. High rate of MDR-I expression without gene amplification was detected in all endometrialcarcinoma samples, as well as in 10 adenomatous hyperplasias and SO samples of normal endometrium. On the other hand, MRP appeared to be expressed at moderate levels in normal endometrial tissue, while relatively high levels of MRP expression without gene amplification were occasionally observed in endometrial-carcinoma samples.