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High protection of animals lethally infected with influenza virus by aprotinin-rimantadine combination

✍ Scribed by Oleg P. Zhirnov

Publisher: John Wiley and Sons
Year: 1987
Tongue: English
Weight: 490 KB
Volume: 21
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.1890210208

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✦ Synopsis

The successful therapeutic synergism of aprotinin and rimantadine, which are known to attack different viral targets, was demonstrated in influenza-virusinfected animals. Combined treatment with these drugs of mice infected with a highly lethal dose of mouse-adapted influenza virus prevented the development of fatal haemorrhagic pneumonia and protected about 75 % of animals; whereas the separate administration of aprotinin and rimantadine induced 35 % and 15 % protection, respectively.

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