High production of nondisjunction mutants in the offspring of Drosophila melanogaster females exposed to carbon dioxide at meiosis I
✍ Scribed by Kazuo Fujikawa; Masahiro Matsubara; Tetsuo Itoh; Sohei Kondo
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 131 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0893-6692
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✦ Synopsis
Drosophila melanogaster females homozygous for trol level when the mating of CO 2 -treated females X-linked recessive markers, y and w i , were exposed was delayed by one day. CO 2 -induced nondisjuncto CO 2 and mated with y / w / /Y males. The prog-tion is probably due to damage to spindle microtueny were sampled and inspected for y w i /y w i /Y bules in mature oocytes at metaphase I. N 2 is a less (XXY) and y / w / /O (XO) mutants. The frequency of potent inducer of nondisjunction than CO 2 . Maternondisjunction XXY mutants after a 90-min exposure nal X-irradiation with 4 Gy did not induce XXY muto CO 2 increased 100-fold above the control level tants, showing that medium-level radiation does not in the first-day brood but did not increase above the induce nondisjunction. The results support Gaulcontrol level in the second to sixth broods, showing den's hypothesis that oxygen deficits and CO 2 inthat CO 2 is an extremely potent inducer of nondis-creases in the microenvironment of mature oocytes junction in mature oocytes during meiotic meta-can be potent inducers of nondisjunction. The possiphase I but is not harmful to immature oocytes. Non-ble relationship to the cluster of Down syndrome disjunction-causing damage induced by CO 2 in ma-seen in Berlin shortly after the Chernobyl accident ture oocytes disappeared completely within one day is discussed.