High production of 1,3-propanediol from glycerol byClostridium butyricumVPI 3266 in a simply controlled fed-batch system

✍ Scribed by S. Saint-Amans; P. Perlot; G. Goma; P. Soucaille

• Publisher: Springer Netherlands
• Year: 1994
• Tongue: English
• Weight: 379 KB
• Volume: 16
• Category: Article
• ISSN: 0141-5492
• DOI: 10.1007/bf00133962

✦ Synopsis

A simple fed-batch system which controls substrate feeding by measuring the CO, produced during the fermentation, was developped. This Fed-batch approach allowed high production of 1,3-propanediol from glycerol by Clostridium butyricum by avoiding substrate inhibition phenomena. 65 g/l of 1,3-propanediol was produced with a productivity of 1.21 g/l.h and a yield of 0.56. The concentration of 1,3-propanediol obtained and the productivity were significantly higher than those reached in batch culture.